Protein Modification Reagents
Medchemexpress LLC Amino-tri-(azide-PEG4-ethoxymethyl)-methane | 99.8% | 1070.20 | 5 MG
Amino-tri-(azide-PEG4-ethoxymethyl)-methane is a multi-arm PEG product, synthesized with high purity of 99.81% to ensure reliable experimental results. This versatile chemical reagent is designed exclusively for research applications.
- High purity, verified at 99.81%.
- Features a multi-arm polyethylene glycol structure.
- Available in multiple quantities to suit diverse research requirements.
- Packaged for stable room temperature shipping.
- Accompanied by comprehensive documentation for reference and safety.
Medchemexpress LLC BTK degrader-1 | 2377645-56-0 | 99.4% | 925.03 | 5 MG
BTK degrader-1 is a Bruton's tyrosine kinase (BTK) bifunctional degrader that can be conjugated with CD79b. It has an anti-tumor effect.
- For research use only
- To be handled by experienced personnel in appropriately equipped and authorized facilities
- Not fully validated for medical applications
Medchemexpress LLC Fmoc-NH-PEG5-C2-NH2 | 2093277-71-3 | 98.1% | 502.60 g/mol | C27H38N2O7 | 5 MG
Fmoc-NH-PEG5-C2-NH2 is an Fmoc-protected PEG-based linker that provides a five-unit PEG spacer and a terminal primary amine for use in the synthesis of PROTACs and other bifunctional molecules. It is intended for medicinal chemistry applications where a flexible, hydrophilic linker and orthogonal protection are required.
- Provides a five-unit polyethylene glycol spacer for flexibility and solubility.
- Contains an Fmoc-protected amine for orthogonal deprotection strategies.
- Includes a terminal primary amine for straightforward coupling to ligands or linkers.
- Suitable for solution- or solid-phase synthesis workflows.
- High purity suitable for research-grade synthesis.
eMolecules Tos-PEG6-t-Butyl ester | Broadpharm | 850090-10-7 | MFCD22683305 | 520.630 | C24H40O10S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 250mg | 208940412
Tos-PEG6-t-Butyl ester | Broadpharm | 850090-10-7 | MFCD22683305 | 520.630 | C24H40O10S | 98.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 250mg | 208940412
Medchemexpress LLC DSPE-PEG-Maleimide ammonium | 99.0% | 2000 | 1 MG
DSPE-PEG-Maleimide (ammonium) (MW 2000) contains DSPE phospholipids and maleimide, used to prepare nanostructured lipid carriers and in drug delivery research.
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Medchemexpress LLC HY-128767 5mg Medchemexpress, VH032-PEG3-acetylene CAS:2098799-80-3 Purity:>98%
Medchemexpress, HY-128767 5mg VH032-PEG3-acetylene CAS:2098799-80-3 VH032-PEG3-acetylene is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Endo-BCN-PEG3-maleimide | 2141976-33-0 | MFCD31811466 | 98.5% | C26H37N3O8 | 10MG
endo-BCN-PEG3-mal is a heterobifunctional PEG-based linker containing a strained bicyclononyne (BCN) moiety and a terminal maleimide. It is designed for bioconjugation workflows, enabling copper-free click chemistry with azides and selective thiol coupling, and is commonly used in linker assembly for targeted degrader and conjugate synthesis.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide partners.
- Provides a thiol-reactive maleimide for selective conjugation.
- Uses a PEG3 spacer to improve solubility and flexibility.
- Suitable for linker synthesis and bioconjugation applications.
- Supplied as an oil with high reported purity.
Medchemexpress LLC PC-biotin-PEG4-NHS carbonate | 2055198-03-1 | 97.0% | C35H50N6O14S | 10MG
PC-Biotin-PEG4-NHS carbonate is a PEG-based photocleavable biotinylation reagent bearing an NHS carbonate amine-reactive group. It is designed for use as a PROTAC linker or to introduce a light-cleavable biotin tag for biochemical conjugation, affinity capture, and downstream light-mediated release of labeled molecules.
- Photocleavable biotin enables light-controlled release of captured molecules.
- PEG4 spacer improves solubility and reduces steric hindrance in conjugates.
- NHS carbonate reacts with primary amines to form stable carbamate linkages.
- High reported purity supports use in synthesis and analytical workflows.
- Powder storage at -20°C and cold-solvent storage extend compound stability.
Medchemexpress LLC Mal-PEG4-propargyl | 1262681-30-0 | MFCD29041878 | 99.7% | C15H21NO6 | 10MG
Mal-PEG4-propargyl is a bifunctional PEG4 linker bearing a maleimide and a propargyl (alkyne) group. It is designed for use in bioconjugation and linker assembly, enabling thiol-maleimide coupling and copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach diverse ligands or linkers.
- Maleimide group enables rapid, selective thiol conjugation.
- Propargyl (alkyne) group supports CuAAC "click" reactions.
- PEG4 spacer improves solubility and reduces steric hindrance.
- Low molecular weight (311.33 g·mol⁻¹) for minimal steric impact.
- High supplied purity (99.7%) for reliable synthetic performance.
CONJU PROBE LLC DBCO-PEG4-Amine | 1255942-08-5 | MFCD22380748 | 100 mg
DBCO-PEG4-Amine | Purity: >95% | Mol Wt: 523.62 | 1255942-08-5 | MFCD22380748 | 100 mg
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 10 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These PROTACs consist of two distinct ligands connected by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets a specific protein. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
